The WNT family of proteins comprises a set of extracellular ligands rich in cysteine residues. WNTs bind to the seven pass transmembrane receptors of the Frizzled family (Yang Snyder et al, 1996) to activate the Dishevelled phosphoproteins in the cytoplasm (Noordermeer et al, 1994). Subsequently, WNT signalling is transduced via both (canonical) and (non canonical) pathway.
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