Interestingly, TNF specifically disrupted tumor associated blood vessels, while leaving normal tissues and blood vessels unharmed. Curnis et al.13 have recently exploited this increase of drug penetration induced by very low doses of TNF for the treatment of melanoma and lymphoma with doxorubicin. To target TNF to the vasculature, TNF was coupled to the GNGRC peptide, a ligand of aminopeptidase N (CD13) that binds specifically to endothelial cells.
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